We are working on design and synthesis of chelate compounds and nanoparticles for biomedical applications. MRI contrast agents, in vitro diagnosis, drug delivery, cancer diagnosis and treatment, and nano-bio interactions are our research subjects.
高锦豪/Jinhao Gao
教授、博士生导师
电话:86-592-2180278
传真:86-592-2189959
办公室:卢嘉锡楼528室
电子邮箱:jhgao(AT)xmu.edu.cn
个人简历:

学士(南京大学 2004)
博士(香港科技大学 2008)
博士后(斯坦福大学 2010)
厦门大学教授,博士生导师(2010.6-至今)
厦门大学化学生物学系主任(2018.9-至今)

香港青年科学家奖(2007),教育部“新世纪优秀人才支持计划”(2010),福建省“闽江学者”特聘教授(2011),国家基金委优秀青年科学基金项目资助(2012),福建省杰出青年科学基金资助(2012),福建省青年拔尖创新人才(2014),中国化学会青年化学奖(2014)

研究兴趣:
功能性有机分子及纳米颗粒的设计合成及其临床应用;对多模式,高分辨的磁共振成像方式的探索;联药合成及体内外肿瘤诊断治疗等。

近期主要代表论著:

(1) Lijiao Yang; Zhenyu Wang; Lengceng Ma; Ao Li; Jingyu Xin; Ruixue Wei; Hongyu Lin.; Ruifang Wang; Zhong Chen; and Jinhao Gao* The Roles of Morphology on the Relaxation Rates of Magnetic Nanoparticles. ACS Nano 2018, 12, 4605-4614.

(2) Lirong Wang; Hongyu Lin; Xiaoqin Chi; Chengjie Sun; Jiaqi Huang; Xiaoxue Tang; Hongming Chen; Xiangjie Luo; Zhenyu Yin; and Jinhao Gao* A Self‐Assembled Biocompatible Nanoplatform for Multimodal MR/Fluorescence Imaging Assisted Photothermal Therapy and Prognosis Analysis. Small 2018, 14, 1801612.

(3) Ruixue Wei; Tiantian Zhou; Chengjie Sun; Hongyu Lin; Lijiao Yang; Bin W. Ren; Zhong Chen; and Jinhao Gao* Iron-oxide-based twin nanoplates with strong T2 relaxation shortening for contrast-enhanced magnetic resonance imaging s. Nanoscale 2018, Accepted Manuscript. 

(4) Lirong Wang; Hongyu Lin; Lingceng Ma; Jianbin Jin; Taipeng Shen; Ruixue Wei; Xiaomin Wang; Hua Ai; Zhong Chen; and  Jinhao Gao* Self‐Assembled Biocompatible Nanoplatform for Multimodal MR/Fluorescence Imaging Assisted Photothermal Therapy and Prognosis Analysis. Nanoscale 2017, 9, 4516-4523.

(5) Lijiao Yang; Lengceng Ma; Jingyu Xin; Ao Li; Chengjie Sun; Ruixue Wei; Bin W. Ren; Zhong Chen; Hongyu Lin; and Jinhao Gao* Composition Tunable Manganese Ferrite Nanoparticles for Optimized T2 Contrast Ability. Chem. Mater. 2017, 29, 3038–3047.

(6) Xianglong Zhu; Hongyu Lin; Lirong Wang; Xiaoxue Tang; Lengceng Ma; Zhong Chen; and Jinhao Gao* Activatable T1 Relaxivity Recovery Nanoconjugates for Kinetic and Sensitive Analysis of Matrix Metalloprotease 2. ACS Appl. Mater. Interfaces, 2017, 9 , 21688–21696.

(7) Zhou, Z. J.; Hu, R.; Wang, L. R.; Sun, C. J; Fu, G .; Gao, J. H.*Water bridge coordination on the metal-rich facets of Gd2O3 nanoplates confers high T1 relaxivity. Nanoscale 2016, 8,17887-17894..

(8) Zhao, Z. H.; Chi, X. Q.; Yang, L. J.; Yang, R.; Ren, B. W.; Zhu, X. L.; Zhang, P.; Gao, J. H.*Cation exchange of anisotropic-shaped magnetite nanoparticles generates high-relaxivity contrast agents for liver tumor imaging. Chem. Mater. 2016, 28,3497-3506.

(9) Ni, K. Y.; Zhao, Z. H.; Zhang, Z. J.; Zhou, Z. J.; Yang, L.; Wang, L. R.; Ai, H.; Gao, J. H.*Geometrically confined ultrasmall gadolinium oxide nanoparticles boost the T1 contrast ability.Nanoscale 2016, 8, 3768-3774.

(10) Zhang, Z. J.; Liu, H. Y.; Zhou, H. L.; Zhu, X. L.; Zhao, Z. H.; Chi, X. Q.; Shan, H.; Gao, J. H.*A facile route to core-shell nanoparticulate formation of arsenic trioxide for effective solid tumor treatment. Nanoscale 2016, 8, 4373-4380.

(11) Zhou, Z. J.; Wu, C. Q.; Liu, H. Y.; Zhu, X. L.; Zhao, Z. H.; Wang, L. R.; Xu, Y.; Ai, H.; Gao, J. H.* Surface and Interfacial Engineering of Iron Oxide Nanoplates for Highly Efficient Magnetic Resonance Angiography. ACS Nano 2015, 9, 3012-3022.

(12) Zhao, Z. H.; Wang, X. M.; Zhang, Z. J.; Zhang, H.; Liu, H. Y.; Zhu, X. L.; Li, H.; Chi, X. Q.; Yin, Z. Y.; Gao, J. H.* Real-Time Monitoring of Arsenic Trioxide Release and Delivery by Activatable T1 Imaging. ACS Nano 2015, 9, 2749-2759.

(13) Zhu, X. L.; Hu, J; Zhao, Z. H.; Sun, M. J.; Chi, X. Q.; Wang, X. M.; Gao, J. H.* Kinetic and Sensitive Analysis of Tyrosinase Activity Using Electron Transfer Complexes: In Vitro and Intracellular Study. Small 2015, 11, 862-870.

(14) Zhou, Z. J.; Zhu, X.; Wu, D.; Chen, Q.; Huang, D.; Sun, C.; Xin, J.; Ni, K.; Gao, J. H.*  Anisotropic Shaped Iron Oxide Nanostructures: Controlled Synthesis and Proton Relaxation Shortening Effects. Chem. Mater. 2015, 27, 3505-3515.

(15) Wang, L. R.; Zhu, X. L.; Tang, X. Y.; Wu, C. Q.; Zhou, Z. J.; Sun, C. J.; Deng, S. L.; Ai, H.;  Gao, J. H.* A Multiple Gadolinium Complexes Decorated Fullerene as a Highly Sensitive T1 Contrast Agent. Chem. Commun. 2015, 51, 4390-4393.

(16) Zhu, X.; Chi, X.; Chen, J.; Wang, L.; Wang, X.; Chen, Z.; Gao, J. H.* Real-Time Monitoring in Vivo Behaviors of Theranostic Nanoparticles by Contrast-Enhanced T1 Imaging. Anal. Chem. 2015, 87, 8941-8948.

(17) Yang, L. J.; Zhou, Z.; Liu, H.; Wu, C.; Zhang, H.; Huang, G.; Ai, H.; Gao, J. H.* Europium-engineered iron oxide nanocubes with high T1 and T2 contrast abilities for MRI in living subjects. Nanoscale 2015, 7, 6843-6850.

(18) Huang, G. M.; Zhu, X. L.; Li, H; Wang, L. R.; Chi, X. Q.; Chen, J. H.; Wang, X. M.; Chen, Z.; Gao, J. H.* Facile integration of multiple magnetite nanoparticles for theranostics combining efficient MRI and thermal therapy. Nanoscale 2015, 7, 2667-2675.

(19) Zhou, Z. J.; Zhao, Z. H.; Zhang, H.; Wang, Z. Y.;  Chen, X. Y.; Wang, R. F.; Chen, Z.; Gao, J. H.* Interplay between Longitudinal and Transverse Contrasts in Fe3O4 Nanoplates with (111) Exposed Surfaces. ACS Nano 2014, 8, 7976-7985.

(20) Huang, G. M.; Li, H; Chen, J. H.; Zhao, Z. H.; Yang, L. J.; Chi, X. Q.; Chen, Z.; Wang, X. M.; Gao, J. H.* Tunable T1 and T2 Contrast Abilities of Manganese-engineered Iron Oxide Nanoparticles through Size Control. Nanoscale 2014, 6, 10404-10412.

(21) Huang, G. M.; Hu, J; Zhang, H.; Zhou, Z. J.; Chi, X. Q.; Gao, J. H.* Highly Magnetic Iron Carbide Nanoparticles as Effective T2 Contrast Agents. Nanoscale 2014, 6, 726-730.

(22) Zhao, Z. H.; Zhou, Z. J.; Bao, J. F.; Wang, Z.; Hu, J.; Chi, X.; Ni, K.; Wang, R. F.; Chen, X. Y.; Chen, Z.; Gao, J. H.* Octapod Iron Oxide Nanoparticles as High-performance T2 Contrast Agents for Magnetic Resonance Imaging. Nature Commun. 2013, 4, 2266.

(23) Zhou, Z. J.; Wang, L. R.; Chi, X. Q.; Bao, J. F.; Yang, L. J.; Zhan, W. X.; Chen, Z.; Wang, X. M.; Chen, X. Y.; Gao, J. H.* Engineered Iron-oxide-based Nanoparticles as Enhanced T1 Contrast Agents for Efficient Tumor Imaging. ACS Nano 2013, 7, 3287-3296.

(24) Zhou, Z. J.; Huang, D. T.; Bao, J. F.; Chen, Q. L.; Liu, G.; Chen, Z.; Chen, X. Y.; Gao, J. H.* A Synergistically Enhanced T1-T2 Dual-Modal Contrast Agent. Adv. Mater. 2012, 24, 6223-6228.

(25) Zhao, Z. H.; Huang, D. T.; Yin, Z. Y.; Chi, X. Q.; Wang, X. M.; Gao, J. H.* Magnetite Nanoparticles as Smart Carriers to Manipulate the Cytotoxicity of Anticancer Drugs: Magnetic Control and pH-Responsive Release. J. Mater. Chem. 2012, 22, 15717-15725.

(26) Chi, X. Q.; Huang, D.T.; Zhao, Z. H.; Zhou, Z. J.; Yin, Z. Y.; Gao, J. H.* Nanoprobes for In Vitro Diagnostics of Cancer and Infectious Diseases. Biomaterials 2012, 33, 189-206.

(27) Gao, J. H.; Chen, K.; Luong, R.; Bouley, D. M.; Mao, H.; Qiao, T.; Gambhir, S. S.; Cheng, Z.* A Novel Clinically Translatable Fluorescent Nanoparticle for Targeted Molecular Imaging of Tumors in Living Subjects. Nano Lett. 2012, 12, 281-286.

(28) Gao, J. H.; Gu, H. W.; Xu, B.* Multifunctional Magnetic Nanoparticles: Design, Synthesis, and Biomedical Applications. Acc. Chem. Res. 2009, 42, 1097-1107.

(29) Gao, J. H.; Liang, G. L.; Cheung, S. C.; Pan, Y.; Kuang, Y.; Zhao, F.; Zhang, B.; Zhang, X. X.; Wu, E. X.; Xu, B.* Multifunctional Yolk-shell Nanoparticles: A Potential MRI Contrast and Anticancer Agent. J. Am. Chem. Soc. 2008, 130, 11828-11833.

(30) Gao, J. H.; Zhang, W.; Huang, P. B.; Zhang, B.; Zhang, X. X.; Xu, B.* Intracellular Control of Fluorescent Magnetic Nanoparticles. J. Am. Chem. Soc. 2008, 130, 3710-3711.

(31) Gao, J. H.; Zhang, B.; Gao, Y.; Pan, Y.; Zhang, X. X.; Xu, B.* Fluorescent Magnetic Nanocrystals by Sequential Addition of Reagents in a One-Pot Reaction: A Simple Preparation for Multifunctional Nanostructures. J. Am. Chem. Soc. 2007, 129, 11928-11935.

(32) Gao, J. H.; Liang, G. L.; Zhang, B.; Kuang, Y.; Zhang, X. X.; Xu, B.* FePt@CoS2 Yolk-shell Nanocrystals as a Potent Agent to Kill HeLa Cells. J. Am. Chem. Soc. 2007, 129, 1428-1433.

(33) Gao, J. H.; Li, L. H.; Ho, P. L.; Mak, G. C.; Gu, H. W.; Xu, B.* Combining Fluorescent Probes and Biofunctional Magnetic Nanoparticles for Rapid Detection of Bacteria in Human Blood. Adv. Mater. 2006, 18, 3145-3148.

(34) Gao, J. H.; Zhang, B.; Zhang, X. X.; Xu, B.* Magnetic Dipolar Interaction Induced Self-Assembly Affords Wires of Cobalt Selenide Hollow Nanoscrystals. Angew. Chem. Int. Ed. 2006, 45, 1220-1223.