We are working on design and synthesis of chelate compounds and nanoparticles for biomedical applications. MRI contrast agents, in vitro diagnosis, drug delivery, cancer diagnosis and treatment, and nano-bio interactions are our research subjects.
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The shape plays a critical role in the contrast ability of magnetic nanoparticles. However, the mechanism on how morphology influences the water proton relaxation process is still unrevealed. We use MnIO NPs of the same geometric volume with six distinct shapes to investigate the relationship between morphologies and T1/T2 relaxation rates. For details, see ACS Nano 2018, 12, 4605-4614.  

Manganese ferrite NPs are promising T2 CAs for MRI. However, how manganese doping alters the contrast ability of magnetite remains critical and yet uncovered. We report a one-pot synthesis of MnxFe3-xO4 NPs with different manganese contents to investigate the effects of manganese doping on changes of ferrite crystal structures, magnetic properties, and contrast abilities. For details, see Chem. Mater. 2017, 29, 3038–3047.

We reported a facile strategy to construct albumin based nanoparticles loaded with hydrophobic gadolinium chelates by hydrophobic interaction for magnetic resonance imaging (MRI). For details, see Small 2018, 14, 1801612.

The octapod iron oxide nanoparticles exhibit an ultrahigh transverse relaxivity, indicating that these octapod iron oxide nanoparticles are promise for highly sensitive, early stage and accurate detection of tumors. For details, see Nat. Commun. 2013, 4, 2266.

We reported an ATO-based multifunctional drug delivery system that efficiently delivers ATO to treat tumors and allows real-time monitoring of ATO release by activatable T1 imaging. For details, see ACS Nano 2015, 9, 2749-2759.

We report the engineering on surface structure of iron oxide nanoplates to boost T1 contrast ability and adjust the in vivo behaviors for highly efficient magnetic resonance angiography (MRA). For details, see ACS Nano 2015, 9, 3012-3022.

Postdoctoral researchers,
graduates, and undergraduates
Welcome to join us

Professor Jinhao Gao

College of Chemistry and
Chemical Engineering,
Xiamen University,
Xiamen 361005, China

Office: R528, Lu Jiaxi Building
Email: jhgao(AT)xmu.edu.cn
Phone: +86-592-2180278