We are working on design and synthesis of chelate compounds and nanoparticles for biomedical applications. MRI contrast agents, in vitro diagnosis, drug delivery, cancer diagnosis and treatment, and nano-bio interactions are our research subjects.
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The octapod iron oxide nanoparticles exhibit an ultrahigh transverse relaxivity, indicating that these octapod iron oxide nanoparticles are promise for highly sensitive, early stage and accurate detection of tumors. For details, see Nat. Commun. 2013, 4, 2266.

We report the engineering on surface structure of iron oxide nanoplates to boost T1 contrast ability and adjust the in vivo behaviors for highly efficient magnetic resonance angiography (MRA). For details, see ACS Nano 2015, 9, 3012-3022.

Embedding metal species with high spins into superparamagnetic iron oxide nanoparticles leads to enhanced local magnetic field strengths by each other under an external magnetic field, resulting in the synergistic enhancement of T1 and T2 relaxivity. For details, see Adv. Mater. 2012, 24, 6223-6228.

Small-sized zwitterion-coated gadolinium-embedded iron oxide nanoparticles exhibited strong T1 contrast effect for tumor imaging through enhanced permeation and retention (EPR) effect and the ability to clear out from body in living subjects. For details, see ACS Nano 2013, 7, 3287-3296.

We reported an ATO-based multifunctional drug delivery system that efficiently delivers ATO to treat tumors and allows real-time monitoring of ATO release by activatable T1 imaging. For details, see ACS Nano 2015, 9, 2749-2759.

We found that nanomaterials induce cell autophagy in a dispersity-dependent manner. Aggregated nanoparticles induce significant autophagic effect in comparison with well-dispersed nanoparticles. For details, see Sci. Rep. 2015, 5, 14361.

Postdoctoral researchers,
graduates, and undergraduates
Welcome to join us

Professor Jinhao Gao

College of Chemistry and
Chemical Engineering,
Xiamen University,
Xiamen 361005, China

Office: R528, Lu Jiaxi Building
Email: jhgao(AT)xmu.edu.cn
Phone: +86-592-2180278